Crystallisation is the preferred separation technology in the pharmaceutical and specialty chemicals industry, since it results in a near 100% pure, solid product delivered in a single process step. The development of industrial crystallisation processes is, however, hampered by the existing design approach, which does not lead to flexibility in product specifications. As a result, major, fundamental problems like limited flexibility, non-linear behaviour and varying product quality cannot be addressed or solved. A paradigm shift from equipment-based to phenomena-based thinking is required to address these fundamental problems in industrial crystallisation. In this project, a new, modular model-based design approach will be developed and demonstrated, aiming at the intensification and optimisation of a crystallisation process for pharmaceutical compounds.
Enhancement of the performance, flexibility and controllability of the process will be realised by applying a novel, phenomena-based design approach, recently developed in Delft. A modular, multi-scale model will allow both local and global optimisation of the crystalliser design. A demonstration unit will be designed on a mini-plant scale and tested with a number of pharmaceutical compounds. The project is part of the OPTICO European research project entitled 'Model-based Optimisation and Control for Process Intensification in Chemical and Biopharmaceutical Systems'. The project will be realised in close cooperation with 11 European partners.
Publication source: http://www.academictransfer.com/13333
Candidates should have the following qualifications:
• an excellent MSc in the area of process engineering (chemical or mechanical) or a related field.
• genuine interest in conceptual thinking, modelling and optimisation
• excellent experimental skills
• fluency in English.
TU Delft offers an attractive benefits package, including a flexible work week, free high-speed Internet access from home (with contracts of two years or longer), and the option of assembling a customised compensation and benefits package (the 'IKA'). Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities.
For more information about this position, please contact Prof. H.J.M. Kramer.
To apply, please e-mail a detailed CV, references, an abstract of your MSc thesis and a publication list, along with a letter of application by 15 April 2012 by the 'apply' button below.
When applying for this position, please refer to vacancy number 3ME12-08.
| Education Backgrounds: |
Chemical Engineering Mechanical Engineering |
| Specialties: |
Lab Analysis Process Engineering Research (R&D) |
| Education Level: |
Postgraduate (Masters) |
| Experience: |
0 - 2 years 2 - 5 years |
| Languages spoken: |
English |
| Job Location: | Delft, Netherlands |
Type: Job
Deadline: 24th August 2012
Job reference (ID): 4690
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